{"id":276,"date":"2023-01-04T07:01:16","date_gmt":"2023-01-04T07:01:16","guid":{"rendered":"https:\/\/www.maryatech.com\/?post_type=product&p=276"},"modified":"2023-01-10T10:06:47","modified_gmt":"2023-01-10T10:06:47","slug":"granulador-farmaceutico","status":"publish","type":"product","link":"https:\/\/www.maryatech.com\/pt\/product\/pharmaceutical-granulator\/","title":{"rendered":"Granulador farmac\u00eautico"},"content":{"rendered":"

Introdu\u00e7\u00e3o b\u00e1sica<\/h3>\n

As formas de dosagem s\u00f3lida comuns s\u00e3o p\u00f3, gr\u00e2nulos, comprimidos, c\u00e1psulas, p\u00edlulas, filmes etc., que representam cerca de 70% das prepara\u00e7\u00f5es farmac\u00eauticas. As caracter\u00edsticas comuns das prepara\u00e7\u00f5es s\u00f3lidas, em compara\u00e7\u00e3o com as prepara\u00e7\u00f5es l\u00edquidas, s\u00e3o a boa estabilidade f\u00edsica e qu\u00edmica, o custo de fabrica\u00e7\u00e3o mais baixo e a facilidade de transporte. Independentemente do processo de produ\u00e7\u00e3o, os procedimentos de granula\u00e7\u00e3o no primeiro est\u00e1gio da produ\u00e7\u00e3o de comprimidos, c\u00e1psulas e gr\u00e2nulos s\u00e3o semelhantes, como mistura, granula\u00e7\u00e3o, secagem e classifica\u00e7\u00e3o etc. Os principais equipamentos s\u00e3o: granulador, m\u00e1quina de moagem e granula\u00e7\u00e3o, misturador geral, m\u00e1quina de comprimidos \/ m\u00e1quina de enchimento de c\u00e1psulas, m\u00e1quina de revestimento etc.<\/p>\n

O princ\u00edpio da granula\u00e7\u00e3o:<\/h3>\n

O princ\u00edpio da granula\u00e7\u00e3o: a opera\u00e7\u00e3o de granula\u00e7\u00e3o faz com que as part\u00edculas tenham algumas finalidades correspondentes, de modo a garantir a qualidade do produto e o bom andamento da produ\u00e7\u00e3o. Por exemplo, se as part\u00edculas s\u00e3o produtos em gr\u00e2nulos e c\u00e1psulas, o objetivo da granula\u00e7\u00e3o n\u00e3o \u00e9 apenas melhorar a fluidez, a dispers\u00e3o e a ades\u00e3o dos materiais, facilitar a medi\u00e7\u00e3o precisa e proteger o ambiente de produ\u00e7\u00e3o, mas tamb\u00e9m garantir a forma e o tamanho uniformes das part\u00edculas, a apar\u00eancia bonita e assim por diante. Na produ\u00e7\u00e3o de comprimidos, as part\u00edculas s\u00e3o produtos intermedi\u00e1rios, n\u00e3o apenas para melhorar a fluidez e reduzir a diferen\u00e7a de peso dos comprimidos, mas tamb\u00e9m para garantir a formabilidade de compress\u00e3o das part\u00edculas. Existem muitos tipos diferentes de m\u00e9todos de granula\u00e7\u00e3o, mesmo com a mesma prescri\u00e7\u00e3o, o conte\u00fado de granula\u00e7\u00e3o n\u00e3o s\u00f3 tem forma, tamanho e resist\u00eancia diferentes, mas tamb\u00e9m tem desintegra\u00e7\u00e3o e solubilidade diferentes, resultando em efeitos pesticidas diferentes. Portanto, o m\u00e9todo de granula\u00e7\u00e3o adequado deve ser selecionado de acordo com as caracter\u00edsticas das part\u00edculas necess\u00e1rias.<\/p>\n

Os m\u00e9todos comuns de granula\u00e7\u00e3o:<\/strong><\/h3>\n

granula\u00e7\u00e3o \u00famida, granula\u00e7\u00e3o em uma etapa, granula\u00e7\u00e3o seca e granula\u00e7\u00e3o por spray.<\/p>\n

O objetivo da granula\u00e7\u00e3o:<\/strong><\/h3>\n
    \n
  • a\u3001Para melhorar a liquidez. De modo geral, o tamanho da part\u00edcula \u00e9 maior do que o do p\u00f3, e o n\u00famero de part\u00edculas que podem ser contatadas ao redor de cada part\u00edcula \u00e9 menor, de modo que a ades\u00e3o e a aglutina\u00e7\u00e3o s\u00e3o bastante enfraquecidas, melhorando muito a fluidez do material. Embora o material seja s\u00f3lido, ele pode ser tratado quantitativamente como um l\u00edquido.<\/li>\n
  • b\u3001Para evitar a separa\u00e7\u00e3o de v\u00e1rios componentes. \u00c9 propenso \u00e0 segrega\u00e7\u00e3o quando o tamanho da part\u00edcula e a densidade de cada componente da mistura s\u00e3o diferentes, e a segrega\u00e7\u00e3o pode ser evitada de forma eficaz pela granula\u00e7\u00e3o ap\u00f3s a mistura ou pela mistura ap\u00f3s a granula\u00e7\u00e3o.<\/li>\n
  • c\u3001Evite que a poeira voe e adira \u00e0 parede. A explos\u00e3o de poeira e a ader\u00eancia do p\u00f3 s\u00e3o graves. Ap\u00f3s a granula\u00e7\u00e3o, a polui\u00e7\u00e3o ambiental e a perda de mat\u00e9rias-primas podem ser evitadas, o que \u00e9 ben\u00e9fico para o gerenciamento de GMP.<\/li>\n
  • Ajuste a densidade de empacotamento para melhorar a solubilidade;<\/li>\n
  • e\u3001Melhorar a transmiss\u00e3o uniforme da press\u00e3o na produ\u00e7\u00e3o de comprimidos;<\/li>\n
  • f\u3001F\u00e1cil de pegar e transportar, aumenta o valor da mercadoria.<\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"

    A m\u00e1quina farmac\u00eautica granuladora \u00e9 a opera\u00e7\u00e3o de processamento de materiais no estado de p\u00f3, l\u00edquido fundido e solu\u00e7\u00e3o aquosa em part\u00edculas de determinada forma e tamanho. O processo de prepara\u00e7\u00e3o de quase todas as prepara\u00e7\u00f5es s\u00f3lidas \u00e9 insepar\u00e1vel do processo de granula\u00e7\u00e3o. As part\u00edculas podem ser produtos acabados, como gr\u00e2nulos, ou produtos intermedi\u00e1rios, como comprimidos.<\/p>","protected":false},"featured_media":449,"template":"","meta":{"om_disable_all_campaigns":false,"_templately_pack_id":"","_templately_imported_at":"","_templately_source":"","_templately_import_session_id":"","site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[48,15],"product_tag":[],"class_list":["post-276","product","type-product","status-publish","has-post-thumbnail","product_cat-pharmaceutical-granulator","product_cat-uncategorized","desktop-align-left","tablet-align-left","mobile-align-left","first","instock","shipping-taxable","product-type-simple"],"yoast_head":"\nPharmaceutical Granulator - 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