{"id":81,"date":"2022-12-08T09:15:53","date_gmt":"2022-12-08T09:15:53","guid":{"rendered":"https:\/\/www.maryatech.com\/?page_id=81"},"modified":"2023-03-08T03:36:40","modified_gmt":"2023-03-08T03:36:40","slug":"solucao-de-medicamento-solido","status":"publish","type":"page","link":"https:\/\/www.maryatech.com\/pt\/solid-medicine-solution\/","title":{"rendered":"Solu\u00e7\u00e3o de medicamento s\u00f3lido"},"content":{"rendered":"
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Solu\u00e7\u00e3o de medicamento s\u00f3lido<\/h2>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Em compara\u00e7\u00e3o com as prepara\u00e7\u00f5es l\u00edquidas, as prepara\u00e7\u00f5es s\u00f3lidas t\u00eam como caracter\u00edsticas comuns melhor estabilidade f\u00edsica e qu\u00edmica, menor custo de fabrica\u00e7\u00e3o e facilidade de transporte. N\u00e3o importa o processo de produ\u00e7\u00e3o, os procedimentos de granula\u00e7\u00e3o na primeira fase da produ\u00e7\u00e3o de comprimidos, c\u00e1psulas e gr\u00e2nulos s\u00e3o semelhantes, como mistura, granula\u00e7\u00e3o, secagem e classifica\u00e7\u00e3o, etc. Os principais equipamentos s\u00e3o: granulador, m\u00e1quina de moagem e granulado, misturador geral, comprimido m\u00e1quina \/ m\u00e1quina de enchimento de c\u00e1psulas, m\u00e1quina de revestimento, etc.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Introdu\u00e7\u00e3o b\u00e1sica<\/p>

\u00a0<\/p>

As formas de dosagem s\u00f3lida comuns s\u00e3o p\u00f3, gr\u00e2nulos, comprimidos, c\u00e1psulas, p\u00edlulas, filmes etc., que representam cerca de 70% das prepara\u00e7\u00f5es farmac\u00eauticas. As caracter\u00edsticas comuns das prepara\u00e7\u00f5es s\u00f3lidas, em compara\u00e7\u00e3o com as prepara\u00e7\u00f5es l\u00edquidas, s\u00e3o a boa estabilidade f\u00edsica e qu\u00edmica, o custo de fabrica\u00e7\u00e3o mais baixo e a facilidade de transporte. Independentemente do processo de produ\u00e7\u00e3o, os procedimentos de granula\u00e7\u00e3o no primeiro est\u00e1gio da produ\u00e7\u00e3o de comprimidos, c\u00e1psulas e gr\u00e2nulos s\u00e3o semelhantes, como mistura, granula\u00e7\u00e3o, secagem e classifica\u00e7\u00e3o etc. Os principais equipamentos s\u00e3o: granulador, m\u00e1quina de moagem e granula\u00e7\u00e3o, misturador geral, m\u00e1quina de comprimidos \/ m\u00e1quina de enchimento de c\u00e1psulas, m\u00e1quina de revestimento, etc.<\/p>

\u00a0<\/p>

Descri\u00e7\u00e3o das caracter\u00edsticas t\u00e9cnicas<\/p>

1. Granulador<\/p>

A granula\u00e7\u00e3o \u00e9 a opera\u00e7\u00e3o de processamento de materiais no estado de p\u00f3, l\u00edquido fundido e solu\u00e7\u00e3o aquosa em part\u00edculas de determinada forma e tamanho. O processo de prepara\u00e7\u00e3o de quase todas as prepara\u00e7\u00f5es s\u00f3lidas \u00e9 insepar\u00e1vel do processo de granula\u00e7\u00e3o. As part\u00edculas podem ser produtos acabados, como gr\u00e2nulos, ou produtos intermedi\u00e1rios, como comprimidos.<\/p>

O princ\u00edpio da granula\u00e7\u00e3o: a opera\u00e7\u00e3o de granula\u00e7\u00e3o faz com que as part\u00edculas tenham algumas finalidades correspondentes, de modo a garantir a qualidade do produto e o bom andamento da produ\u00e7\u00e3o. Por exemplo, se as part\u00edculas s\u00e3o produtos em gr\u00e2nulos e c\u00e1psulas, o objetivo da granula\u00e7\u00e3o n\u00e3o \u00e9 apenas melhorar a fluidez, a dispers\u00e3o e a ades\u00e3o dos materiais, facilitar a medi\u00e7\u00e3o precisa e proteger o ambiente de produ\u00e7\u00e3o, mas tamb\u00e9m garantir a forma e o tamanho uniformes das part\u00edculas, a apar\u00eancia bonita e assim por diante. Na produ\u00e7\u00e3o de comprimidos, as part\u00edculas s\u00e3o produtos intermedi\u00e1rios, n\u00e3o apenas para melhorar a fluidez e reduzir a diferen\u00e7a de peso dos comprimidos, mas tamb\u00e9m para garantir a formabilidade de compress\u00e3o das part\u00edculas. Existem muitos tipos diferentes de m\u00e9todos de granula\u00e7\u00e3o, mesmo com a mesma prescri\u00e7\u00e3o, o conte\u00fado de granula\u00e7\u00e3o n\u00e3o s\u00f3 tem forma, tamanho e resist\u00eancia diferentes, mas tamb\u00e9m tem desintegra\u00e7\u00e3o e solubilidade diferentes, resultando em efeitos pesticidas diferentes. Portanto, o m\u00e9todo de granula\u00e7\u00e3o adequado deve ser selecionado de acordo com as caracter\u00edsticas das part\u00edculas necess\u00e1rias.<\/p>

Os m\u00e9todos comuns de granula\u00e7\u00e3o: granula\u00e7\u00e3o \u00famida, granula\u00e7\u00e3o em uma etapa, granula\u00e7\u00e3o seca e granula\u00e7\u00e3o por spray.<\/p>

O objetivo da granula\u00e7\u00e3o:<\/p>

a\u3001Para melhorar a liquidez. De modo geral, o tamanho da part\u00edcula \u00e9 maior do que o do p\u00f3, e o n\u00famero de part\u00edculas que podem ser contatadas ao redor de cada part\u00edcula \u00e9 menor, de modo que a ades\u00e3o e a aglutina\u00e7\u00e3o s\u00e3o bastante enfraquecidas, melhorando muito a fluidez do material. Embora o material seja s\u00f3lido, ele pode ser tratado quantitativamente como um l\u00edquido.<\/p>

b\u3001Para evitar a separa\u00e7\u00e3o de v\u00e1rios componentes. \u00c9 propenso \u00e0 segrega\u00e7\u00e3o quando o tamanho da part\u00edcula e a densidade de cada componente da mistura s\u00e3o diferentes, e a segrega\u00e7\u00e3o pode ser evitada de forma eficaz pela granula\u00e7\u00e3o ap\u00f3s a mistura ou pela mistura ap\u00f3s a granula\u00e7\u00e3o.<\/p>

c\u3001Evite que a poeira voe e adira \u00e0 parede. A explos\u00e3o de poeira e a ader\u00eancia do p\u00f3 s\u00e3o graves. Ap\u00f3s a granula\u00e7\u00e3o, a polui\u00e7\u00e3o ambiental e a perda de mat\u00e9rias-primas podem ser evitadas, o que \u00e9 ben\u00e9fico para o gerenciamento de GMP.<\/p>

d\u3001Ajuste a densidade de empacotamento para melhorar a solubilidade;<\/p>

e\u3001Melhorar a transmiss\u00e3o uniforme da press\u00e3o na produ\u00e7\u00e3o de comprimidos;<\/p>

f\u3001F\u00e1cil de pegar e transportar, aumenta o valor da mercadoria.<\/p>

2. M\u00e1quina de moagem e granula\u00e7\u00e3o<\/p>

A m\u00e1quina tem as vantagens da granula\u00e7\u00e3o r\u00e1pida e do bom efeito. O filtro com furo especial \u00e9 projetado e filtrado cuidadosamente. A haste do filtro de fric\u00e7\u00e3o pode quebrar a peneira e filtrar as part\u00edculas. Essa m\u00e1quina pode substituir o granulador oscilante. \u00c9 um novo tipo de m\u00e1quina projetada e fabricada de acordo com os requisitos de GMP da produ\u00e7\u00e3o de medicamentos. A m\u00e1quina inteira \u00e9 vedada com uma placa de a\u00e7o inoxid\u00e1vel de alta qualidade. A apar\u00eancia de toda a m\u00e1quina \u00e9 limpa e bonita, especialmente a tela \u00e9 feita de malha de arame ou malha de a\u00e7o inoxid\u00e1vel, o que melhora muito a qualidade e a efici\u00eancia econ\u00f4mica das part\u00edculas.<\/p>

A m\u00e1quina \u00e9 usada principalmente para part\u00edculas aglomeradas secas na ind\u00fastria farmac\u00eautica, separando part\u00edculas uniformes qualificadas de acordo com os requisitos do processo, e para misturador e prensa de comprimidos. Ela \u00e9 amplamente utilizada nos setores de API, qu\u00edmico, aliment\u00edcio e outros;<\/p>

Uso: Tritura\u00e7\u00e3o e granula\u00e7\u00e3o de mat\u00e9rias-primas granulares grosseiras, mat\u00e9rias-primas de aglutina\u00e7\u00e3o, comprimidos que n\u00e3o atendem aos requisitos; tritura\u00e7\u00e3o e reciclagem de alimentos sens\u00edveis ao calor, biscoitos gordurosos e cremosos.<\/p>

Caracter\u00edsticas de desempenho:<\/p>

a\u3001Menos calor e menos poeira no trabalho<\/p>

b\u3001A tela do estator \u00e9 feita de a\u00e7o inoxid\u00e1vel e n\u00e3o \u00e9 f\u00e1cil de ser danificada.<\/p>

c\u3001Limite ajust\u00e1vel entre a faca de tritura\u00e7\u00e3o e a tela<\/p>

3. Misturador geral<\/p>

Mistura refere-se ao processo de opera\u00e7\u00e3o no qual a velocidade e a dire\u00e7\u00e3o do material mudam sob a influ\u00eancia de for\u00e7as externas (gravidade e for\u00e7a mec\u00e2nica, etc.), de modo que as part\u00edculas de cada componente possam ser distribu\u00eddas uniformemente. Tamb\u00e9m \u00e9 chamado de processo de homogeneiza\u00e7\u00e3o.<\/p>

Classifica\u00e7\u00e3o: de acordo com o modo de movimento da mistura,<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"

Solid Medicine Solution Compared with the liquid preparations, solid preparations have the common characteristics of better physical and chemical stability, lower manufacturing cost, and convenience in taking and carrying. No matter what production process, the granulation procedures at the first stage of tablet, capsule and granule production are similar, such as mixing, granulation, drying and […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_templately_pack_id":"","_templately_imported_at":"","_templately_source":"","_templately_import_session_id":"","site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-81","page","type-page","status-publish","hentry"],"yoast_head":"\nSolid Medicine Solution - Shanghai Marya<\/title>\n<meta name=\"description\" content=\"Solid Medicine Solution Compared with the liquid preparations, solid preparations have the common characteristics of better physical and chemical\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.maryatech.com\/pt\/solucao-de-medicamento-solido\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Solid Medicine Solution\" \/>\n<meta property=\"og:description\" content=\"Solid Medicine Solution Compared with the liquid preparations, solid preparations have the common characteristics of better physical and chemical\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.maryatech.com\/pt\/solucao-de-medicamento-solido\/\" \/>\n<meta property=\"og:site_name\" content=\"Shanghai Marya Pharmaceutical Engineering & Project Co., Ltd.\" \/>\n<meta property=\"article:modified_time\" content=\"2023-03-08T03:36:40+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.maryatech.com\/wp-content\/uploads\/2022\/12\/cropped-Marya-scaled.png\" \/>\n\t<meta property=\"og:image:width\" content=\"2560\" \/>\n\t<meta property=\"og:image:height\" content=\"840\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@Shanghai_Marya\" \/>\n<meta name=\"twitter:label1\" content=\"Est. tempo de leitura\" \/>\n\t<meta name=\"twitter:data1\" content=\"7 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.maryatech.com\\\/solid-medicine-solution\\\/\",\"url\":\"https:\\\/\\\/www.maryatech.com\\\/solid-medicine-solution\\\/\",\"name\":\"Solid Medicine Solution - 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