{"id":276,"date":"2023-01-04T07:01:16","date_gmt":"2023-01-04T07:01:16","guid":{"rendered":"https:\/\/www.maryatech.com\/?post_type=product&p=276"},"modified":"2023-01-10T10:06:47","modified_gmt":"2023-01-10T10:06:47","slug":"farmacijas-granulators","status":"publish","type":"product","link":"https:\/\/www.maryatech.com\/lv\/product\/pharmaceutical-granulator\/","title":{"rendered":"Farmaceitiskais granulators"},"content":{"rendered":"

Ievads pamatos<\/h3>\n

Izplat\u012bt\u0101k\u0101s ciet\u0101s z\u0101\u013cu formas ir pulveris, granulas, tabletes, kapsulas, pilienu tabletes, pl\u0113ve u. c., kas veido aptuveni 70% farmaceitisko prepar\u0101tu. Sal\u012bdzinot ar \u0161\u0137idrajiem prepar\u0101tiem, cietajiem prepar\u0101tiem ir rakstur\u012bga laba fizik\u0101l\u0101 un \u0137\u012bmisk\u0101 stabilit\u0101te, zem\u0101kas ra\u017eo\u0161anas izmaksas, tie ir viegli lietojami un p\u0101rn\u0113s\u0101jami. Neatkar\u012bgi no ra\u017eo\u0161anas procesa, granul\u0113\u0161anas proced\u016bras table\u0161u, kapsulu un granulu ra\u017eo\u0161anas pirmaj\u0101 posm\u0101 ir l\u012bdz\u012bgas, piem\u0113ram, sajauk\u0161ana, granul\u0113\u0161ana, \u017e\u0101v\u0113\u0161ana un \u0161\u0137iro\u0161ana utt. Galven\u0101s iek\u0101rtas ir \u0161\u0101das: granulators, smalcin\u0101\u0161anas un granul\u0113\u0161anas iek\u0101rta, visp\u0101r\u0113jais mais\u012bt\u0101js, table\u0161u\/kapsulu pild\u012b\u0161anas iek\u0101rta, p\u0101rkl\u0101\u0161anas iek\u0101rta utt.<\/p>\n

Granul\u0113\u0161anas princips:<\/h3>\n

\u25b6 Granul\u0113\u0161anas princips: granul\u0113\u0161anas oper\u0101cijas rezult\u0101t\u0101 da\u013ci\u0146\u0101m ir da\u017ei atbilsto\u0161i m\u0113r\u0137i, lai nodro\u0161in\u0101tu produkta kvalit\u0101ti un vienm\u0113r\u012bgu ra\u017eo\u0161anas gaitu. Piem\u0113ram, ja da\u013ci\u0146as ir produkti granul\u0101s un kapsul\u0101s, granul\u0113\u0161anas m\u0113r\u0137is ir ne tikai uzlabot materi\u0101lu pl\u016bstam\u012bbu, dispersiju un sa\u0137eri, atvieglot prec\u012bzus m\u0113r\u012bjumus un aizsarg\u0101t ra\u017eo\u0161anas vidi, bet ar\u012b nodro\u0161in\u0101t da\u013ci\u0146u viendab\u012bgu formu un izm\u0113ru, skaistu izskatu utt. Table\u0161u ra\u017eo\u0161an\u0101 da\u013ci\u0146as ir starpprodukti, un to m\u0113r\u0137is ir ne tikai uzlabot pl\u016bstam\u012bbu, lai samazin\u0101tu table\u0161u svara starp\u012bbu, bet ar\u012b nodro\u0161in\u0101t da\u013ci\u0146u saspie\u017eam\u012bbu. Ir daudz da\u017e\u0101du granul\u0113\u0161anas meto\u017eu, pat ja ir vien\u0101da recepte, granul\u0113\u0161anas saturam ir ne tikai at\u0161\u0137ir\u012bga forma, izm\u0113rs un stipr\u012bba, bet ar\u012b at\u0161\u0137ir\u012bga sadal\u012b\u0161an\u0101s un \u0161\u0137\u012bd\u012bba, kas rada at\u0161\u0137ir\u012bgu pestic\u012bdu iedarb\u012bbu. T\u0101p\u0113c piem\u0113rota granul\u0113\u0161anas metode j\u0101izv\u0113las atbilsto\u0161i vajadz\u012bgo da\u013ci\u0146u \u012bpa\u0161\u012bb\u0101m.<\/p>\n

Parast\u0101s granul\u0113\u0161anas metodes:<\/strong><\/h3>\n

mitr\u0101 granul\u0113\u0161ana, vienpak\u0101pju granul\u0113\u0161ana, saus\u0101 granul\u0113\u0161ana un izsmidzin\u0101\u0161anas granul\u0113\u0161ana.<\/p>\n

Granul\u0113\u0161anas m\u0113r\u0137is:<\/strong><\/h3>\n
    \n
  • a\u3001Likvidit\u0101tes uzlabo\u0161anai. Visp\u0101r\u012bgi run\u0101jot, da\u013ci\u0146u izm\u0113rs ir liel\u0101ks nek\u0101 pulverim, un da\u013ci\u0146u skaits, kas var saskarties ap katru da\u013ci\u0146u, ir maz\u0101ks, t\u0101p\u0113c sa\u0137ere un aglutin\u0101cija iev\u0113rojami pav\u0101jin\u0101s, t\u0101d\u0113j\u0101di iev\u0113rojami uzlabojot materi\u0101la pl\u016bstam\u012bbu. Lai gan materi\u0101ls ir ciets, tom\u0113r to var apstr\u0101d\u0101t tikpat kvantitat\u012bvi k\u0101 \u0161\u0137idrumu.<\/li>\n
  • b\u3001Lai nov\u0113rstu da\u017e\u0101du komponentu atdal\u012b\u0161anu. Ja katras mais\u012bjuma sast\u0101vda\u013cas da\u013ci\u0146u izm\u0113rs un bl\u012bvums ir at\u0161\u0137ir\u012bgs, ir tendence segreg\u0101cijai, un segreg\u0101ciju var efekt\u012bvi nov\u0113rst ar granul\u0113\u0161anu p\u0113c sajauk\u0161anas vai sajauk\u0161anu p\u0113c granul\u0113\u0161anas.<\/li>\n
  • c\u3001nov\u0113r\u0161 putek\u013cu lidin\u0101\u0161anu un pielip\u0161anu pie sienas. Putek\u013cu spr\u0101dziens un pulvera pielip\u0161ana ir nopietna probl\u0113ma. P\u0113c granul\u0113\u0161anas var nov\u0113rst vides pies\u0101r\u0146ojumu un izejvielu zudumus, kas ir izdev\u012bgi GMP p\u0101rvald\u012bbai.<\/li>\n
  • Piel\u0101gojiet iepakojuma bl\u012bvumu, lai uzlabotu \u0161\u0137\u012bd\u012bbu;<\/li>\n
  • e\u3001Izlabot vienm\u0113r\u012bgu spiediena p\u0101rnesi table\u0161u ra\u017eo\u0161an\u0101;<\/li>\n
  • f\u3001 Viegli \u0146emt un p\u0101rn\u0113s\u0101t, uzlabo preces v\u0113rt\u012bbu.<\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"

    Farmaceitisk\u0101 ma\u0161\u012bna granulators ir darb\u012bba, kas saist\u012bta ar materi\u0101lu p\u0101rstr\u0101di pulvera, k\u016bsto\u0161a \u0161\u0137idruma un \u016bdens \u0161\u0137\u012bduma veid\u0101 noteiktas formas un izm\u0113ra da\u013ci\u0146\u0101s. Gandr\u012bz visu cieto prepar\u0101tu sagatavo\u0161anas process ir neatdal\u0101ms no granul\u0113\u0161anas procesa. Da\u013ci\u0146as var b\u016bt gatavie produkti, piem\u0113ram, granulas, vai starpprodukti, piem\u0113ram, tabletes.<\/p>","protected":false},"featured_media":449,"template":"","meta":{"om_disable_all_campaigns":false,"_templately_pack_id":"","_templately_imported_at":"","_templately_source":"","_templately_import_session_id":"","site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[48,15],"product_tag":[],"class_list":["post-276","product","type-product","status-publish","has-post-thumbnail","product_cat-pharmaceutical-granulator","product_cat-uncategorized","desktop-align-left","tablet-align-left","mobile-align-left","first","instock","shipping-taxable","product-type-simple"],"yoast_head":"\nPharmaceutical Granulator - 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