{"id":81,"date":"2022-12-08T09:15:53","date_gmt":"2022-12-08T09:15:53","guid":{"rendered":"https:\/\/www.maryatech.com\/?page_id=81"},"modified":"2023-03-08T03:36:40","modified_gmt":"2023-03-08T03:36:40","slug":"ciets-zalu-skidums","status":"publish","type":"page","link":"https:\/\/www.maryatech.com\/lv\/solid-medicine-solution\/","title":{"rendered":"Cietais medic\u012bnas risin\u0101jums"},"content":{"rendered":"
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Cietais medic\u012bnas risin\u0101jums<\/h2>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Sal\u012bdzinot ar \u0161\u0137idrajiem prepar\u0101tiem, cietajiem prepar\u0101tiem ir kop\u012bgas \u012bpa\u0161\u012bbas \u2013 lab\u0101ka fizik\u0101l\u0101 un \u0137\u012bmisk\u0101 stabilit\u0101te, zem\u0101kas ra\u017eo\u0161anas izmaksas un \u0113rt\u012bba pa\u0146em\u0161an\u0101 un p\u0101rn\u0113s\u0101\u0161an\u0101. Neatkar\u012bgi no ra\u017eo\u0161anas procesa granul\u0113\u0161anas proced\u016bras table\u0161u, kapsulu un granulu ra\u017eo\u0161anas pirmaj\u0101 posm\u0101 ir l\u012bdz\u012bgas, piem\u0113ram, sajauk\u0161ana, granul\u0113\u0161ana, \u017e\u0101v\u0113\u0161ana un \u0161\u0137iro\u0161ana utt. Galven\u0101s iek\u0101rtas ir: granulators, sl\u012bp\u0113\u0161anas un granul\u0113\u0161anas ma\u0161\u012bna, visp\u0101r\u0113jais mais\u012bt\u0101js, tablete. ma\u0161\u012bna \/ kapsulu iepild\u012b\u0161anas ma\u0161\u012bna, p\u0101rkl\u0101\u0161anas ma\u0161\u012bna utt.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Ievads pamatos<\/p>

\u00a0<\/p>

Izplat\u012bt\u0101k\u0101s ciet\u0101s z\u0101\u013cu formas ir pulveris, granulas, tabletes, kapsulas, pilienu tabletes, pl\u0113ve u. c., kas veido aptuveni 70% farmaceitisko prepar\u0101tu. Sal\u012bdzinot ar \u0161\u0137idrajiem prepar\u0101tiem, cietajiem prepar\u0101tiem ir rakstur\u012bga laba fizik\u0101l\u0101 un \u0137\u012bmisk\u0101 stabilit\u0101te, zem\u0101kas ra\u017eo\u0161anas izmaksas, tie ir viegli lietojami un p\u0101rn\u0113s\u0101jami. Neatkar\u012bgi no ra\u017eo\u0161anas procesa, granul\u0113\u0161anas proced\u016bras table\u0161u, kapsulu un granulu ra\u017eo\u0161anas pirmaj\u0101 posm\u0101 ir l\u012bdz\u012bgas, piem\u0113ram, sajauk\u0161ana, granul\u0113\u0161ana, \u017e\u0101v\u0113\u0161ana un \u0161\u0137iro\u0161ana utt. Galven\u0101s iek\u0101rtas ir \u0161\u0101das: granulators, smalcin\u0101\u0161anas un granul\u0113\u0161anas iek\u0101rta, visp\u0101r\u0113jais mais\u012bt\u0101js, table\u0161u\/kapsulu pild\u012b\u0161anas iek\u0101rta, p\u0101rkl\u0101\u0161anas iek\u0101rta utt.<\/p>

\u00a0<\/p>

Tehnisk\u0101s funkcijas Apraksts<\/p>

1. Granulators<\/p>

\u25b6 Granul\u0113\u0161ana ir darb\u012bba, kad materi\u0101lus pulvera, k\u016bsto\u0161a \u0161\u0137idruma un \u016bdens \u0161\u0137\u012bduma veid\u0101 p\u0101rstr\u0101d\u0101 noteiktas formas un lieluma da\u013ci\u0146\u0101s. Gandr\u012bz visu cieto prepar\u0101tu sagatavo\u0161anas process ir neatdal\u0101ms no granul\u0113\u0161anas procesa. Da\u013ci\u0146as var b\u016bt gatavi produkti, piem\u0113ram, granulas, vai starpprodukti, piem\u0113ram, tabletes.<\/p>

\u25b6 Granul\u0113\u0161anas princips: granul\u0113\u0161anas darb\u012bba padara da\u013ci\u0146\u0101m atbilsto\u0161us m\u0113r\u0137us, lai nodro\u0161in\u0101tu produkta kvalit\u0101ti un vienm\u0113r\u012bgu ra\u017eo\u0161anas gaitu. Piem\u0113ram, ja da\u013ci\u0146as ir produkti granul\u0101s un kapsul\u0101s, granul\u0113\u0161anas m\u0113r\u0137is ir ne tikai uzlabot materi\u0101lu pl\u016bstam\u012bbu, dispersiju un adh\u0113ziju, k\u0101 ar\u012b atvieglot prec\u012bzu m\u0113r\u012bjumu veik\u0161anu un aizsarg\u0101t ra\u017eo\u0161anas vidi, bet ar\u012b nodro\u0161in\u0101t da\u013ci\u0146u vien\u0101du formu un izm\u0113ru. , skaists izskats un t\u0101 t\u0101l\u0101k. Table\u0161u ra\u017eo\u0161an\u0101 da\u013ci\u0146as ir starpprodukti, tas ir paredz\u0113ts ne tikai pl\u016bstam\u012bbas uzlabo\u0161anai, lai samazin\u0101tu table\u0161u svara starp\u012bbu, bet ar\u012b nodro\u0161in\u0101tu da\u013ci\u0146u pres\u0113jam\u012bbu. Ir daudz da\u017e\u0101du granul\u0113\u0161anas meto\u017eu, pat ja vienai receptei granul\u0113\u0161anas saturam ir ne tikai at\u0161\u0137ir\u012bga forma, izm\u0113rs un stiprums, bet ar\u012b at\u0161\u0137ir\u012bga sadal\u012b\u0161an\u0101s un \u0161\u0137\u012bd\u012bba, k\u0101 rezult\u0101t\u0101 ir at\u0161\u0137ir\u012bga pestic\u012bdu iedarb\u012bba. T\u0101p\u0113c piem\u0113rot\u0101 granul\u0113\u0161anas metode j\u0101izv\u0113las atbilsto\u0161i nepiecie\u0161amo da\u013ci\u0146u \u012bpa\u0161\u012bb\u0101m.<\/p>

\u25b6 Izplat\u012bt\u0101s granul\u0113\u0161anas metodes: mitr\u0101 granul\u0113\u0161ana, vienpak\u0101pes granul\u0113\u0161ana, saus\u0101 granul\u0113\u0161ana un izsmidzin\u0101\u0161anas granul\u0113\u0161ana.<\/p>

\u25b6 Granul\u0113\u0161anas m\u0113r\u0137is:<\/p>

a\u3001Lai uzlabotu likvidit\u0101ti. Visp\u0101r\u012bgi run\u0101jot, da\u013ci\u0146u izm\u0113rs ir liel\u0101ks nek\u0101 pulvera da\u013ci\u0146u izm\u0113rs, un da\u013ci\u0146u skaits, ar kur\u0101m var saskarties ap katru da\u013ci\u0146u, ir maz\u0101ks, t\u0101p\u0113c adh\u0113zija un aglutin\u0101cija ir iev\u0113rojami v\u0101jin\u0101ta, t\u0101d\u0113j\u0101di iev\u0113rojami uzlabojot materi\u0101la pl\u016bstam\u012bbu. Lai gan materi\u0101ls ir ciets, bet kvantitat\u012bvi to var uzskat\u012bt par \u0161\u0137idrumu.<\/p>

b\u3001Lai nov\u0113rstu da\u017e\u0101du komponentu atdal\u012b\u0161anu. Tas ir pak\u013cauts segreg\u0101cijai, ja katras mais\u012bjuma sast\u0101vda\u013cas da\u013ci\u0146u izm\u0113rs un bl\u012bvums ir at\u0161\u0137ir\u012bgs, un segreg\u0101ciju var efekt\u012bvi nov\u0113rst, granul\u0113jot p\u0113c sajauk\u0161anas vai sajaucot p\u0113c granul\u0113\u0161anas.<\/p>

c\u3001Nov\u0113rsiet putek\u013cu lido\u0161anu un pielip\u0161anu pie sienas. Putek\u013cu eksplozija un pulvera sa\u0137ere ir nopietna. P\u0113c granul\u0113\u0161anas var nov\u0113rst vides pies\u0101r\u0146ojumu un izejvielu zudumus, kas ir izdev\u012bgi LRP p\u0101rvald\u012bbai.<\/p>

d\u3001Piel\u0101gojiet iepakojuma bl\u012bvumu, lai uzlabotu \u0161\u0137\u012bd\u012bbu;<\/p>

e. Uzlabot vienm\u0113r\u012bgu spiediena p\u0101rne\u0161anu table\u0161u ra\u017eo\u0161an\u0101;<\/p>

f\u3001 Viegli \u0146emt un p\u0101rn\u0113s\u0101t, uzlabo preces v\u0113rt\u012bbu.<\/p>

2. Sasmalcin\u0101\u0161anas un granul\u0113\u0161anas iek\u0101rta<\/p>

\u25b6 Ma\u0161\u012bnai ir \u0101tras granul\u0113\u0161anas un laba efekta priek\u0161roc\u012bbas. Sieti\u0146\u0161 ar speci\u0101lu caurumu ir izstr\u0101d\u0101ts un r\u016bp\u012bgi filtr\u0113ts. Berzes filtra stienis var salauzt sietu un filtra da\u013ci\u0146as. \u0160\u012b iek\u0101rta var aizst\u0101t \u0161\u016bpojo\u0161o granulatoru. T\u0101 ir jauna veida ma\u0161\u012bna, kas izstr\u0101d\u0101ta un ra\u017eota saska\u0146\u0101 ar LRP pras\u012bb\u0101m z\u0101\u013cu ra\u017eo\u0161an\u0101. Visa iek\u0101rta ir nosl\u0113gta ar augstas kvalit\u0101tes ner\u016bs\u0113jo\u0161\u0101 t\u0113rauda pl\u0101ksni. Visas ma\u0161\u012bnas izskats ir gl\u012bts un skaists, jo \u012bpa\u0161i ekr\u0101ns ir izgatavots no stiep\u013cu sieta vai ner\u016bs\u0113jo\u0161\u0101 t\u0113rauda sieta, kas iev\u0113rojami uzlabo da\u013ci\u0146u kvalit\u0101ti un ekonomisko efektivit\u0101ti.<\/p>

\u25b6 Ma\u0161\u012bnu galvenok\u0101rt izmanto \u017e\u0101v\u0113tu aglomer\u0113tu da\u013ci\u0146u ieg\u016b\u0161anai farm\u0101cijas r\u016bpniec\u012bb\u0101, \u0161\u0137irojot kvalific\u0113tas viendab\u012bgas da\u013ci\u0146as atbilsto\u0161i procesa pras\u012bb\u0101m, k\u0101 ar\u012b mais\u012bt\u0101ju un table\u0161u preses vajadz\u012bb\u0101m. To pla\u0161i izmanto API, \u0137\u012bmijas, p\u0101rtikas un cit\u0101s nozar\u0113s;<\/p>

\u25b6 Lieto\u0161ana: rupjo granulu izejvielu, sa\u0137eres izejvielu, pras\u012bb\u0101m neatbilsto\u0161u table\u0161u smalcin\u0101\u0161ana un granul\u0113\u0161ana; termiski jut\u012bgas p\u0101rtikas, taukainu un kr\u0113mveida cepumu sasmalcin\u0101\u0161ana un p\u0101rstr\u0101de.<\/p>

\u25b6 Veiktsp\u0113jas funkcijas:<\/p>

a\u3001maz\u0101ks karstums un maz\u0101k putek\u013cu darba laik\u0101<\/p>

b\u3001Statora siets ir izgatavots no ner\u016bs\u0113jo\u0161\u0101 t\u0113rauda, un to nav viegli saboj\u0101t.<\/p>

c\u3001Regul\u0113jama atstarpe starp drupin\u0101\u0161anas asmeni un sietu<\/p>

3. Visp\u0101r\u0113jais mikseris<\/p>

\u25b6 Sajauk\u0161ana attiecas uz darb\u012bbas procesu, kur\u0101 \u0101r\u0113ju sp\u0113ku (gravit\u0101cijas un meh\u0101nisk\u0101 sp\u0113ka uc) ietekm\u0113 main\u0101s materi\u0101la \u0101trums un virziens, lai katras sast\u0101vda\u013cas da\u013ci\u0146as var\u0113tu vienm\u0113r\u012bgi sadal\u012bties. To sauc ar\u012b par homogeniz\u0101cijas procesu.<\/p>

\u25b6 Klasifik\u0101cija: atbilsto\u0161i mais\u012b\u0161anas kust\u012bbas re\u017e\u012bmam,<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"

Solid Medicine Solution Compared with the liquid preparations, solid preparations have the common characteristics of better physical and chemical stability, lower manufacturing cost, and convenience in taking and carrying. No matter what production process, the granulation procedures at the first stage of tablet, capsule and granule production are similar, such as mixing, granulation, drying and […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_templately_pack_id":"","_templately_imported_at":"","_templately_source":"","_templately_import_session_id":"","site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-81","page","type-page","status-publish","hentry"],"yoast_head":"\nSolid Medicine Solution - 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