{"id":276,"date":"2023-01-04T07:01:16","date_gmt":"2023-01-04T07:01:16","guid":{"rendered":"https:\/\/www.maryatech.com\/?post_type=product&p=276"},"modified":"2023-01-10T10:06:47","modified_gmt":"2023-01-10T10:06:47","slug":"granulateur-pharmaceutique","status":"publish","type":"product","link":"https:\/\/www.maryatech.com\/fr\/product\/pharmaceutical-granulator\/","title":{"rendered":"Granulateur pharmaceutique"},"content":{"rendered":"

Introduction de base<\/h3>\n

Les formes de dosage solides les plus courantes sont la poudre, le granul\u00e9, le comprim\u00e9, la capsule, la goutte, le film, etc., qui repr\u00e9sentent environ 70% des pr\u00e9parations pharmaceutiques. Les caract\u00e9ristiques communes des pr\u00e9parations solides par rapport aux pr\u00e9parations liquides sont une bonne stabilit\u00e9 physique et chimique, un co\u00fbt de fabrication plus faible et une facilit\u00e9 de prise et de transport. Quel que soit le processus de production, les proc\u00e9dures de granulation au premier stade de la production de comprim\u00e9s, de g\u00e9lules et de granul\u00e9s sont similaires, comme le m\u00e9lange, la granulation, le s\u00e9chage et le tri, etc. Les principaux \u00e9quipements sont : le granulateur, la machine \u00e0 broyer et \u00e0 granuler, le m\u00e9langeur g\u00e9n\u00e9ral, la machine \u00e0 comprim\u00e9s \/ machine de remplissage de g\u00e9lules, la machine d'enrobage, etc.<\/p>\n

Le principe de la granulation :<\/h3>\n

\u25b6 Le principe de la granulation : l'op\u00e9ration de granulation permet aux particules d'avoir des objectifs correspondants, afin de garantir la qualit\u00e9 du produit et le bon d\u00e9roulement de la production. Par exemple, si les particules sont des produits en granul\u00e9s et en capsules, l'objectif de la granulation est non seulement d'am\u00e9liorer la fluidit\u00e9, la dispersion et l'adh\u00e9rence des mat\u00e9riaux, de faciliter une mesure pr\u00e9cise et de prot\u00e9ger l'environnement de production, mais aussi de garantir la forme et la taille uniformes des particules, une belle apparence, etc. Dans la production de comprim\u00e9s, les particules sont des produits interm\u00e9diaires. Il s'agit non seulement d'am\u00e9liorer la fluidit\u00e9 pour r\u00e9duire la diff\u00e9rence de poids des comprim\u00e9s, mais aussi d'assurer la formabilit\u00e9 des particules par compression. Il existe de nombreux types de m\u00e9thodes de granulation, m\u00eame si la prescription est la m\u00eame, le contenu de la granulation a non seulement une forme, une taille et une r\u00e9sistance diff\u00e9rentes, mais aussi une d\u00e9sint\u00e9gration et une solubilit\u00e9 diff\u00e9rentes, ce qui se traduit par des effets diff\u00e9rents sur les pesticides. Par cons\u00e9quent, la m\u00e9thode de granulation appropri\u00e9e doit \u00eatre s\u00e9lectionn\u00e9e en fonction des caract\u00e9ristiques des particules requises.<\/p>\n

Les m\u00e9thodes de granulation les plus courantes :<\/strong><\/h3>\n

granulation humide, granulation en une \u00e9tape, granulation s\u00e8che et granulation par pulv\u00e9risation.<\/p>\n

L'objectif de la granulation :<\/strong><\/h3>\n
    \n
  • a\u3001Am\u00e9liorer la liquidit\u00e9. D'une mani\u00e8re g\u00e9n\u00e9rale, la taille des particules est sup\u00e9rieure \u00e0 celle des poudres, et le nombre de particules pouvant entrer en contact autour de chaque particule est inf\u00e9rieur, de sorte que l'adh\u00e9sion et l'agglutination sont consid\u00e9rablement affaiblies, ce qui am\u00e9liore grandement la fluidit\u00e9 du mat\u00e9riau. Bien que le mat\u00e9riau soit solide, il peut \u00eatre trait\u00e9 quantitativement comme un liquide.<\/li>\n
  • b\u3001Pour \u00e9viter la s\u00e9paration des diff\u00e9rents composants. Il y a tendance \u00e0 la s\u00e9gr\u00e9gation lorsque la taille des particules et la densit\u00e9 de chaque composant du m\u00e9lange sont diff\u00e9rentes, et la s\u00e9gr\u00e9gation peut \u00eatre efficacement \u00e9vit\u00e9e par la granulation apr\u00e8s le m\u00e9lange ou le m\u00e9lange apr\u00e8s la granulation.<\/li>\n
  • c\u3001Pr\u00e9venir les envols de poussi\u00e8re et l'adh\u00e9rence sur le mur. L'explosion de poussi\u00e8re et l'adh\u00e9rence de la poudre sont graves. Apr\u00e8s la granulation, la pollution de l'environnement et la perte de mati\u00e8res premi\u00e8res peuvent \u00eatre \u00e9vit\u00e9es, ce qui est b\u00e9n\u00e9fique pour la gestion des BPF.<\/li>\n
  • Ajuster la densit\u00e9 de tassement pour am\u00e9liorer la solubilit\u00e9 ;<\/li>\n
  • e\u3001Am\u00e9liorer la transmission uniforme de la pression dans la production de comprim\u00e9s ;<\/li>\n
  • f\u3001Facile \u00e0 prendre et \u00e0 transporter, am\u00e9liore la valeur de la marchandise.<\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"

    Le granulateur pharmaceutique est l'op\u00e9ration qui consiste \u00e0 transformer des mat\u00e9riaux \u00e0 l'\u00e9tat de poudre, de liquide de fusion et de solution aqueuse en particules d'une forme et d'une taille d\u00e9termin\u00e9es. Le processus de pr\u00e9paration de presque toutes les pr\u00e9parations solides est indissociable du processus de granulation. Les particules peuvent \u00eatre des produits finis, tels que des granul\u00e9s, ou des produits interm\u00e9diaires, tels que des comprim\u00e9s.<\/p>","protected":false},"featured_media":449,"template":"","meta":{"om_disable_all_campaigns":false,"_templately_pack_id":"","_templately_imported_at":"","_templately_source":"","_templately_import_session_id":"","site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[48,15],"product_tag":[],"class_list":["post-276","product","type-product","status-publish","has-post-thumbnail","product_cat-pharmaceutical-granulator","product_cat-uncategorized","desktop-align-left","tablet-align-left","mobile-align-left","first","instock","shipping-taxable","product-type-simple"],"yoast_head":"\nPharmaceutical Granulator - 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